Istradefylline | B3013

Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing dyskinesias or hyperactivity in an MPTP-induced marmoset model of Parkinson's disease. It also decreases bradykinesia and improves attentional and working memory deficits induced by L-DOPA in an MPTP-induced macaque model of Parkinson's disease.

Istradefylline is an adenosine receptor 2A (A2A) antagonist with a Ki value of 2.2 nM in a radioligand binding assay. Oral administration of Istradefylline reverses motor disability without inducing dyskinesias or hyperactivity in an MPTP-induced marmoset model of Parkinson's disease. It also decreases bradykinesia and improves attentional and working memory deficits induced by L-DOPA in an MPTP-induced macaque model of Parkinson's disease.

B3013 | Istradefylline DataSheet

Alternate Name/Synonyms: KW-6002; 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine; 8-[2-(3,4-Dimethoxy-phenyl)-vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-purine-2,6-dione; 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

Appearance: White to off-white solid powder

Formulation:

CAS Number: 155270-99-8

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₀H₂₄N₄O₄

Molecular Weight: 384.4

Cell-Permeable?: TRUE

Purity: >95%

Solubilities: ~8 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An adenosine receptor 2A (A2A) antagonist

MDL Number: MFCD00928421

PubChem CID: 5311037

SMILES: CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C

InChi: InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+

InChi Key: IQVRBWUUXZMOPW-PKNBQFBNSA-N