ITE | B1579

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Mechanically, ITE bound AhR inhibits transcription of OCT4, an inducer of pluripotent stem cells, through direct binding to OCT4 promoter. As a consequence, ITE treatment significantly represses the tumor formation in xenograft model using injection of U87 cells.

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). It enhances differentiation of cancer stem-like cells detected by the decrease of sphere formation and proliferation from glioblastoma cells U87. Mechanically, ITE bound AhR inhibits transcription of OCT4, an inducer of pluripotent stem cells, through direct binding to OCT4 promoter. As a consequence, ITE treatment significantly represses the tumor formation in xenograft model using injection of U87 cells.

B1579 | ITE DataSheet

Alternate Name/Synonyms: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester; Aryl hydrocarbon receptor ligand

Appearance: Yellow solid

Formulation: N/A

CAS Number: 448906-42-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₄H₁₀N₂O₃S

Molecular Weight: 286.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An endogenous aryl hydrocarbon receptor (AhR) agonist

MDL Number: N/A

PubChem CID: 4668801

SMILES: COC(=O)C1=CSC(=N1)C(=O)C2=CNC3=CC=CC=C32

InChi: InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3

InChi Key: KDDXOGDIPZSCTM-UHFFFAOYSA-N