ITPKB polyclonal Antibody | BS70584

ITPKB polyclonal Antibody | BS70584 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB 1:200 - 1:2000 IHC 1:20 - 1:200

Background: Inositol 1,4,5-trisphosphate (Ins (1,4,5) P3) regulates the level of calcium within the cell by releasing calcium from intracellular stores. Ins (1,4,5) P3 is phosphorylated by inositol 1,4,5-trisphosphate 3-kinase (IP3K) to form inositol 1,3,4,5-tetrakisphosphate (Ins (1,4,5) P4), which is is thought to regulate the influx of calcium across the plasma membrane. IP3K exists as three isoforms, IP3KA, B, and C. IP3KA, the most highly characterized isoform, is expressed in rat brain and testis. IP3KB is expressed in various rat tissues such as lung, thymus, testis, brain, and heart. IP3K activity is stimulated in the presence of calmodulin via phosphorylation by cAMP-dependent protein kinase, protein kinase C, or calcium/calmodulin dependent protein kinase II and, subsequently, mediates the inositol phosphate signaling pathways.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ITPKB polyclonal Antibody detects endogenous levels of ITPKB protein.

Molecular Weight: ~ 102 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB;

Immunogen: Recombinant protein of human ITPKB.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: