ITPR2 polyclonal Antibody | BS90745

ITPR2 polyclonal Antibody | BS90745 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: DotBlot ICC IHC FC

Application Range: DotBlot:1:2,000-1:5,000 ICC:1:50-1:100 IHC:1:50-1:200 FC:1:50-1:100

Background: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: ITPR2 polyclonal Antibody detects endogenous levels of ITPR2 protein.

Molecular Weight: 308 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2, 4, 5-trisphosphate receptor, Inositol 1 4 5 trisphosphate receptor type 2, Inositol 1, 4, 5-trisphosphate receptor type 2, Inositol 145 trisphosphate receptor type 2, InsP3 R2, InsP3R2, IP3 R2, IP3 receptor, IP3 receptor isoform 2, IP3R 2, IP3R2, ITPR 2, Itpr2, ITPR2, Type 2 inositol 1 4 5 trisphosphate receptor, Type 2 inositol 1, Type 2 inositol 145 trisphosphate receptor, Type 2 InsP3 receptor,

Immunogen: Recombinant protein within human ITPR2 aa 1100-1450.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: