Description
Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis.
ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation.
Alternate Name/Synonyms: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide, ITSA1
Appearance: White solid
Formulation: N/A
CAS Number: 200626-61-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₃H₇Cl₂N₃O
Molecular Weight: 292.12
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A suppressor of Trichostatin A (TSA)
MDL Number: MFCD00195103
PubChem CID: 771910
SMILES: C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl
InChi: InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
InChi Key: UVNLAUGZMOPBPR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |