ITSA-1 | 2089

Cell-permeable. ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation. ITSA-1 also reverses TSA induced cell cycle arrest and apoptosis.

ITSA-1 is a suppressor of Trichostatin A (TSA) and a molecular tool for dissecting gene regulation by distinct acetylation events (histone and tubulin). ITSA-1 specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. ITSA-1 reverses TSA induced histone acetylation, overall deacetylation.

2089 | ITSA-1 DataSheet

Alternate Name/Synonyms: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide, ITSA1

Appearance: White solid

Formulation: N/A

CAS Number: 200626-61-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₃H₇Cl₂N₃O

Molecular Weight: 292.12

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A suppressor of Trichostatin A (TSA)

MDL Number: MFCD00195103

PubChem CID: 771910

SMILES: C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl

InChi: InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H

InChi Key: UVNLAUGZMOPBPR-UHFFFAOYSA-N