Ivachtin | 2788

Ivachtin is a potent, reversible and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) that displays 10-100 fold selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK (Cat. Nos. 1010 and 1140).

Ivachtin is a potent, reversible and non-competitive inhibitor of caspase-3 (IC₅₀ = 23 nM) that displays 10-100 fold selectivity over other caspases. Exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine; exhibits a higher level of protection than Z-VAD-FMK (Cat. Nos. 1010 and 1140).

2788 | Ivachtin DataSheet

Alternate Name/Synonyms: 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate

Appearance: Tan solid

Formulation: N/A

CAS Number: 745046-84-8

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₁N₃O₇S

Molecular Weight: 447.46

Cell-Permeable?: Y

Purity: ≥98% by HPLC

Solubilities: DMSO (>4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A caspase-3 inhibitor

MDL Number: MFCD09971108

PubChem CID: 11201705

SMILES: CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C

InChi: InChI=1S/C20H21N3O7S/c1-12-17-18(20(26)23(19(17)25)7-10-30-13(2)24)15-11-14(3-4-16(15)21-12)31(27,28)22-5-8-29-9-6-22/h3-4,11H,5-10H2,1-2H3

InChi Key: CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)C