IWP-3 | 2349

An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM).

2349 | IWP-3 DataSheet

Alternate Name/Synonyms: Inhibitor of Wnt Production-3; 2-​[[3-​(4-​fluorophenyl)-​3,​4,​6,​7-​tetrahydro-​4-​oxothieno[3,​2-​ d]pyrimidin-​2-​yl]thio]-​N-​(6-​methyl-​2-​benzothiazolyl)-​acetamide

Appearance: White to Off-white Solid

Formulation: N/A

CAS Number: 687561-60-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₁₇FN₄O₂S₃

Molecular Weight: 484.59

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~2 mg/ml on warming)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of Wnt production

MDL Number: MFCD04457889

PubChem CID: N/A

SMILES: O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=C(F)C=C5)=O

InChi: InChI=1S/C22H17FN4O2S3/c1-12-2-7-15-17(10-12)32-21(24-15)26-18(28)11-31-22-25-16-8-9-30-19(16)20(29)27(22)14-5-3-13(23)4-6-14/h2-7,10H,8-9,11H2,1H3,(H,24,26,28)

InChi Key: XVMHQSDMKWQNBK-UHFFFAOYSA-N