Ixazomib | B2384

Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is a biologically active form of MLN9708. MLN-2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models.

Ixazomib (MLN-2238), is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL-2238 is a biologically active form of MLN9708. MLN-2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models.

B2384 | Ixazomib DataSheet

Alternate Name/Synonyms: (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid, MLN2238, MLN-2238

Appearance: White solid

Formulation:

CAS Number: 1072833-77-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₄H₁₉BCl₂N₂O₄

Molecular Weight: 361.03

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >25 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent proteasome inhibitor

MDL Number:

PubChem CID: 25183872

SMILES: B(C(CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O

InChi: InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

InChi Key: MXAYKZJJDUDWDS-LBPRGKRZSA-N