JAK Inhibitor, Pyridone 6 | 2534

Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.

JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC₅₀ values of 15, 1, and 5 nM, respectively. Displays significantly weaker affinities (IC₅₀s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC₅₀ values of 50-100 nM.

2534 | JAK Inhibitor, Pyridone 6 DataSheet

Alternate Name/Synonyms: 2-​(1,​1-​Dimethylethyl)-​9-​fluoro-​1,​6-​dihydro-​7H-​benz[h]imidazo[4,​5-​f]isoquinolin-​7-​one; Pyridone 6; CMP 6

Appearance: Off-white solid

Formulation: N/A

CAS Number: 457081-03-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆FN₃O

Molecular Weight: 309.3

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK inhibitor

MDL Number: MFCD17019334

PubChem CID: 5494425

SMILES: CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O

InChi: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)

InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N