Jasplakinolide, jaspis johnstoni | 1689

A cell- permeable, non-fluorescent F-actin probe. Displays antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization, Jasplakinolide competes with phallotoxins for actin binding (Kd = 15 nM). It also enhances apoptosis induced by IL-2 deprivation.

Jasplakinolide is a cell- permeable, non-fluorescent F-actin probe. A potent inducer of actin polymerization and stabilization, Jasplakinolide competes with phallotoxins for actin binding (Kd = 15 nM). It also enhances apoptosis induced by IL-2 deprivation.

1689 | Jasplakinolide, jaspis johnstoni DataSheet

Alternate Name/Synonyms:

Appearance: Off-white to yellow solid

Formulation: N/A

CAS Number: 102396-24-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₆H₄₅BrN₄O₆

Molecular Weight: 709.67

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO or MeOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-fluorescent F-actin probe

MDL Number: MFCD00873735

PubChem CID: 6436289

SMILES: CC1CC(OC(=O)CC(NC(=O)C(N(C(=O)C(NC(=O)C(CC(=C1)C)C)C)C)CC2=C(NC3=CC=CC=C32)Br)C4=CC=C(C=C4)O)C

InChi: InChI=1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22+,23-,24-,30+,31+/m0/s1

InChi Key: GQWYWHOHRVVHAP-HZIRKPFGSA-N