JFD00244 | B2830

JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM. It induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4 at a concentration of 5 μM.

JFD00244 is an inhibitor of SIRT2. SIRT2 is a NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. A major substrate of SIRT2 is α-tubulin. JFD00244 inhibits SIRT2 with an IC₅₀ of 56.7 µM. It induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4 at a concentration of 5 μM.

B2830 | JFD00244 DataSheet

Alternate Name/Synonyms: 1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione; 1,4-bis[2-(p-hydroxyphenyl)ethylamino]anthraquinone; BML-266

Appearance: Crystalline solid

Formulation:

CAS Number: 96969-83-4

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₃₀H₂₆N₂O₄

Molecular Weight: 478.54

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~0.3 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of SIRT2

MDL Number: MFCD00208443

PubChem CID: 2817242

SMILES: C1=CC=C2C(=C1)C(=O)C3=C(C=CC(=C3C2=O)NCCC4=CC=C(C=C4)O)NCCC5=CC=C(C=C5)O

InChi: InChI=1S/C30H26N2O4/c33-21-9-5-19(6-10-21)15-17-31-25-13-14-26(32-18-16-20-7-11-22(34)12-8-20)28-27(25)29(35)23-3-1-2-4-24(23)30(28)36/h1-14,31-34H,15-18H2

InChi Key: UUJHFIBEJJLZBF-UHFFFAOYSA-N