JGB1741 | B2804

JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 μM, 10 μM and 0.5 μM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP.

JGB1741 is a small molecule inhibitor of SIRT1. The sirtuins (SIRTs) are NAD+-dependent histone deacetylases. The IC₅₀ value of JGB1741 in a cell-free assay is 15 μM. The IC₅₀ for cell proliferation of three cancer cell lines, K562, HepG2 and MDA-MB 231 is 1 μM, 10 μM and 0.5 μM, respectively. JGB1741 causes cytochrome c release, modulation in Bax/Bcl2 ratio and cleavage of PARP.

B2804 | JGB1741 DataSheet

Alternate Name/Synonyms: 4,5,6,7-tetrahydro-2-[(E)-[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(phenylmethyl)-benzo[b]thiophene-3-carboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1256375-38-8

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₇H₂₄N₂O₂S

Molecular Weight: 440.56

Cell-Permeable?: True

Purity: ≥98%

Solubilities: 0.2 mg/ml in in DMSO, ~0.14 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A small molecule inhibitor of SIRT1

MDL Number:

PubChem CID: 136232142

SMILES: C1CCC2=C(C1)C(=C(S2)N=CC3=C(C=CC4=CC=CC=C43)O)C(=O)NCC5=CC=CC=C5

InChi: InChI=1S/C27H24N2O2S/c30-23-15-14-19-10-4-5-11-20(19)22(23)17-29-27-25(21-12-6-7-13-24(21)32-27)26(31)28-16-18-8-2-1-3-9-18/h1-5,8-11,14-15,17,30H,6-7,12-13,16H2,(H,28,31)/b29-17+

InChi Key: CRTIXRJWHKMWCH-STBIYBPSSA-N