JK 184 | 1726

An imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC₅₀ = 210 nM).

JK 184 is an imidazopyridine derivative that acts as a potent downstream antagonist of Hedgehog(Hh) signaling pathway. JK184 functions by inhibiting class IV alcohol dehydrogenase (Aldh7) (IC₅₀ = 210 nM).

1726 | JK 184 DataSheet

Alternate Name/Synonyms: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-y l)-2-thiazolamine

Appearance: Beige solid

Formulation: N/A

CAS Number: 315703-52-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₈N₄OS

Molecular Weight: 350.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mM) and Ethanol (25 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A hedgehog(Hh) signaling pathway antagonist

MDL Number: MFCD01044465

PubChem CID: 1069686

SMILES: CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C

InChi: InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)

InChi Key: ROYXIPOUVGDTAO-UHFFFAOYSA-N