JNJ-27018966 | B1109

JNJ-27018966 is an orally active μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, with powerful antidiarrheal and analgesic activity. It is believed to act locally in the enteric nervous system, and has no adverse effects in the central nervous system.

JNJ-27018966 is an orally active μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist, with powerful antidiarrheal and analgesic activity. It is believed to act locally in the enteric nervous system, and has no adverse effects in the central nervous system.

B1109 | JNJ-27018966 DataSheet

Alternate Name/Synonyms: 5-(((S)-2-amino-3-(4-carbamoyl-2,6-dimethylphenyl)-N-((S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl)propanamido)methyl)-2-methoxybenzoic acid; Eluxadoline; Viberzi

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 864821-90-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₅N₅O₅

Molecular Weight: 569.66

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A μ- and κ-opioid receptor agonist and δ-opioid receptor antagonist

MDL Number: N/A

PubChem CID: 11250029

SMILES: CC1=CC(=CC(=C1CC(C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)C(C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N

InChi: InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1

InChi Key: QFNHIDANIVGXPE-FNZWTVRRSA-N