BW
JNK1/2/3 (Phospho-T183) Rabbit monoclonal Antibody | BS9939M
- SKU:
- BW-BS9939M
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- Usually ships in 5 working days
Description
JNK1/2/3 (Phospho-T183) Rabbit monoclonal Antibody | BS9939M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB ICC/IF IHC FC
Application Range: WB: 1:1000-1:2000 IHC/ICC/IF: 1:50-1:200 FC: 1:50-1:100
Background: The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced) .
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of JNK1 protein only when phosphorylated at Thr183. This Antibody also recognizes JNK2 and JNK3 when phosphorylated at the corresponding residues.
Molecular Weight: ~ 46, 54 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: JNK 46; JNK 55; JNK; JNK1; JNK1A2; JNK2; JNK21B1/2; JNK2ALPHA; JNK2B; JNK2BETA; JNK3; JNK3A; MAP kinase 8; MAP kinase 9; MAP kinase p49 3F12; MAPK 8; MAPK 9; MAPK10; MAPK8; MAPK9; MGC50974; Mitogen activated protein kinase 10; Mitogen activated protein kinase 8; Mitogen activated protein kinase 9;
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Phosphorylation
Purification & Purity: Protein A affinity purified
Pathway: