JNK1/3 polyclonal Antibody | BS90752

JNK1/3 polyclonal Antibody | BS90752 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IP

Application Range: WB:1:1,000-1:2,000

Background: c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced) .

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: JNK1/3 polyclonal Antibody detects endogenous levels of JNK1/3 protein.

Molecular Weight: 48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MAP kinase 8, MAPK 8, SAPK1c, MAPK8, MAP kinase 10, MAPK 10, SAPK1b, MAPK10, c Jun N terminal kinase 3, c Jun N-terminal kinase 1, JNK 46, JNK, JNK1, JNK1A2, JNK21B1/2, JNK3 alpha protein kinase, JNK3, JNK3A, JUN N terminal kinase, MAP kinase 10, MAP kinase 8, MAP kinase p49 3F12, MAPK 10, MAPK10, MAPK8, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 8 isoform JNK1 alpha1, Mitogen activated protein kinase 8 isoform JNK1 beta2, p493F12, p54bSAPK, PRKM10, PRKM8, SAPK1, SAPK1b, SAPK1c, Stress activated protein kinase 1, Stress activated protein kinase 1b, Stress activated protein kinase 1c, Stress activated protein kinase beta, Stress activated protein kinase JNK3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: