JNK1+JNK2+JNK3 Polyclonal Antibody | BS65605

JNK1+JNK2+JNK3 Polyclonal Antibody | BS65605 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, (predicted: Dog, Pig, Cow, )

Application: WB,IHC-P,

Application Range: WB=1:500-2000 IHC-P=1:100-500

Background: JNK1 (MAPK8) is a member of the MAP kinase family. JNK1 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. JNK2 (p54a, SAPK1a), along with JNK1 and JNK3, is thought to play an important role in nuclear signal transduction through its environmental stress activation and subsequent phosphorylation of the nuclear transcription factor p53. JNK3 is a neuron-specific form of c-Jun N-terminal kinases. Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. The JNK pathway is critically involved in diabetes and levels are abnormally elevated in obesity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: JNK1+JNK2+JNK3 Polyclonal Antibody detects endogenous levels of JNK1+JNK2+JNK3 protein.

Molecular Weight: 42-52 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: JNK1 + JNK2 + JNK3; JNK1/2/3; JNK1+2+3; JNK1 + JNK2 + JNK3; MAPK10; c Jun N terminal kinase 1; c Jun N terminal kinase 2; c Jun N terminal kinase 3; JNK; JNK1; JNK2; JNK2ALPHA; JNK2BETA; JNK3; MAPK8; MAPK9; Mitogen activated protein kinase 10; Mitogen activated protein kinase 8; Mitogen activated protein kinase 9; SAPK (beta) ; Stress activated protein kinase JNK1; Stress activated protein kinase JNK2; Stress activated protein kinase JNK3; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA.

Immunogen: KLH conjugated synthetic peptide derived from human JNK1/2/3:151-250/384

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: