JNK2 Polyclonal Antibody | E-AB-15735

JNK2 Polyclonal Antibody | E-AB-15735 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: c Jun kinase 2, C Jun N terminal kinase 2, c-Jun N-terminal kinase 2, JNK 55, JNK-55, JNK2 alpha, JNK2, JNK2 beta, JNK2A, JNK2alpha, JNK2B, JNK2BETA, Jun kinase, MAP kinase 9, MAPK 9, Mapk9, Mitogen activated protein kinase 9, Mitogen-activated protein kinase 9, MK09, P54a, p54aSAPK, PRKM9, Protein kinase, mitogen-activated, 9, SAPK alpha, SAPK, SAPK1a, Stress activated protein kinase 1a, Stress-activated protein kinase JNK2

Application: WB, IHC, ELISA

Reactivity: Human , Mouse , Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cell Biology, Metabolism, Immunology, Signal Transduction

Background: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

Concentration: 0.4 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human MAPK9

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 48 kDa

Molecular Weight(Observed): Refer to figures