K02288 | B2321

A potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling.

K02288 is a potent and selective inhibitor of type I bone morphogenic protein (BMP) receptors (IC₅₀ values are 1.1, 1.8, 6.4, 34.4, 220, 302 and 321 nM for ALK2, ALK1, ALK6, ALK3, ActRIIA, ALK4 and ALK5 respectively). K02288 can prevent BMP4-induced SMAD1/5/8 pathway activation in vitro (IC₅₀ = 100 nM) without affecting TGF-β signaling.

B2321 | K02288 DataSheet

Alternate Name/Synonyms: 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol

Appearance: Off-white solid

Formulation:

CAS Number: 1431985-92-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₂₀N₂O₄

Molecular Weight: 352.38

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Type I bone morphogenic protein (BMP) receptors inhibitors

MDL Number:

PubChem CID: 46173038

SMILES: COC1=CC(=CC(=C1OC)OC)C2=C(N=CC(=C2)C3=CC(=CC=C3)O)N

InChi: InChI=1S/C20H20N2O4/c1-24-17-9-13(10-18(25-2)19(17)26-3)16-8-14(11-22-20(16)21)12-5-4-6-15(23)7-12/h4-11,23H,1-3H3,(H2,21,22)

InChi Key: CJLMANFTWLNAKC-UHFFFAOYSA-N