K252a | 2013

An analog of Staurosporine (Cat. No. 1048) that acts as a non-selective protein kinase inhibitor. Iinhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Potently inhibits CaMK (Ki = 1.8 nM), competitively with ATP and noncompetitively with the substrate.

K252a is an analog of Staurosporine (Cat. No. 1048) that acts as a non-selective protein kinase inhibitor. Iinhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Potently inhibits CaMK (Ki = 1.8 nM), competitively with ATP and noncompetitively with the substrate.

2013 | K252a DataSheet

Alternate Name/Synonyms: SF 2370

Appearance: White solid

Formulation: N/A

CAS Number: 99533-80-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₁N₃O₅

Molecular Weight: 467.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective protein kinase inhibitor

MDL Number: MFCD00161522

PubChem CID: 127357

SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O

InChi:

InChi Key: KOZFSFOOLUUIGY-UHOLRESSSA-N