KCNJ11 Antibody | 15-407

KCNJ11 Antibody | 15-407 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: A synthetic peptide of human KCNJ11

Research Area: Cancer, Neuroscience, Signal Transduction

Tested Application: WB, Flow

Application: WB: 1:500 - 1:2000
Flow: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: Mouse heart

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 44kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, pH7.3.

Concentration: N/A

Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.

Alternate Name: KCNJ11, potassium inwardly-rectifying channel, subfamily J, member 11, BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3, ATP-sensitive inward rectifier potassium channel 11, beta-cell inward rectifier subunit, inwardly rectifying potassium channel KIR6.2,

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) , an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM) , transient neonatal diabetes mellitus type 3 (TNDM3) , and permanent neonatal diabetes mellitus (PNDM) . Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.