KCNJ11 Polyclonal Antibody | E-AB-11188

KCNJ11 Polyclonal Antibody | E-AB-11188 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: ATP sensitive inward rectifier potassium channel 11, Beta cell inward rectifier subunit, BIR, HHF 2, HHF2, IKATP, Inward rectifier K(+) channel Kir6.2, Inwardly rectifying potassium channel KIR6.2, IRK 11, IRK11, KCNJ11, Kir 6.2, Kir6.2, MGC133230, PHHI, Potassium channel inwardly rectifing subfamily J member 11, Potassium channel, inwardly rectifying subfamily J member 11, Potassium inwardly rectifying channel J11, TNDM 3, TNDM3

Application: IHC, ELISA

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction

Background: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human KCNJ11

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A