KCNJ16 Antibody (Center) [AMM06107G]

KCNJ16 Antibody (Center) [AMM06107G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: Rat

Specificity: This KCNJ16 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 286-319 amino acids from the Central region of human KCNJ16.

Cellular Localisation: Membrane; Multi- pass membrane protein. Basolateral cell membrane. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10

Molecular Weight: 47949

Clone: Polyclonal

Gene Name: KCNJ16

Gene ID: 3773

Function: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K (+) recycling in distal tubules; this process is critical for Na (+) reabsorption at the tubules (PubMed:24561201) .

Summary: Tissue Location: Widely expressed, with highest levels in adult and fetal kidney (at protein level) . In the kidney, expressed in the proximal and distal convoluted tubules, but not in glomeruli nor collecting ducts.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Inward rectifier potassium channel 16, Inward rectifier K (+) channel Kir51, Potassium channel, inwardly rectifying subfamily J member 16, KCNJ16