KCNJ6 Antibody (Center) [AMM06130G]

KCNJ6 Antibody (Center) [AMM06130G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KCNJ6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the Central region of human KCNJ6.

Cellular Localisation: Membrane; Multi-pass membrane protein.

Molecular Weight: 48451

Clone: Polyclonal

Gene Name: KCNJ6

Gene ID: 3763

Function: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G- protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Summary: Tissue Location: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: G protein-activated inward rectifier potassium channel 2, GIRK-2, BIR1, Inward rectifier K (+) channel Kir32, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6, KCNJ6, GIRK2, KATP2, KCNJ7