KCTD17 Antibody (Center) [AMM06179G]

KCTD17 Antibody (Center) [AMM06179G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KCTD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the Central region of human KCTD17.

Cellular Localisation: Cytoplasm.

Molecular Weight: 35670

Clone: Polyclonal

Gene Name: KCTD17

Gene ID: 79734

Function: Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate- adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598) . May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243) .

Summary: Tissue Location: Highly expressed in brain. Highest expression is observed in the putamen and the thalamus

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: BTB/POZ domain-containing protein KCTD17, KCTD17