KD 5170 | B2820

KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human tumor-derived cell lines. It inhibited xenograft tumors in nude mice.

KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human tumor-derived cell lines. It inhibited xenograft tumors in nude mice.

B2820 | KD 5170 DataSheet

Alternate Name/Synonyms: S-[2-[6-[[4-[3-(dimethylamino)propoxy]phenyl]sulfonylamino]pyridin-3-yl]-2-oxoethyl] ethanethioate, S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate

Appearance: Crystalline solid

Formulation:

CAS Number: 940943-37-3

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₂₅N₃O₅S₂

Molecular Weight: 451.56

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~1 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A histone deacetylase inhibitor

MDL Number:

PubChem CID: 17754557

SMILES: CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C

InChi: InChI=1S/C20H25N3O5S2/c1-15(24)29-14-19(25)16-5-10-20(21-13-16)22-30(26,27)18-8-6-17(7-9-18)28-12-4-11-23(2)3/h5-10,13H,4,11-12,14H2,1-3H3,(H,21,22)

InChi Key: KXWBUKMWZKTHCV-UHFFFAOYSA-N