Description
KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human tumor-derived cell lines. It inhibited xenograft tumors in nude mice.
KD 5170 is a broad spectrum, classes I and II HDAC (histone deacetylase) inhibitor. The IC₅₀ for inhibition of HDAC1, HDAC2, HDAC3, HDAC4 is 0.02 μM, 2 μM, 0.075 μM, 0.026 μM respectively, in vitro. KD5170 induced apoptosis in a broad range of human tumor-derived cell lines. It inhibited xenograft tumors in nude mice.
Alternate Name/Synonyms: S-[2-[6-[[4-[3-(dimethylamino)propoxy]phenyl]sulfonylamino]pyridin-3-yl]-2-oxoethyl] ethanethioate, S-(2-(6-(4-(3-(Dimethylamino)propoxy)phenylsulfonamido)pyridin-3-yl)-2-oxoethyl) ethanethioate
Appearance: Crystalline solid
Formulation:
CAS Number: 940943-37-3
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₀H₂₅N₃O₅S₂
Molecular Weight: 451.56
Cell-Permeable?: True
Purity: ≥98%
Solubilities: ~1 mg/ml in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A histone deacetylase inhibitor
MDL Number:
PubChem CID: 17754557
SMILES: CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C
InChi: InChI=1S/C20H25N3O5S2/c1-15(24)29-14-19(25)16-5-10-20(21-13-16)22-30(26,27)18-8-6-17(7-9-18)28-12-4-11-23(2)3/h5-10,13H,4,11-12,14H2,1-3H3,(H,21,22)
InChi Key: KXWBUKMWZKTHCV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |