KH7 | 2350

A selective inhibitor of soluble adenylyl cyclase (sAC) ( IC₅₀ = 3-10 µM in vivo). Displays little effect on transmembrane adenylyl cyclases. KH7 is not active against sAC in the presence of detergents. At concentrations above 50 µM, KH7 exhibits non-specific membrane disruption effects when used on cells.

KH7 is a selective inhibitor of soluble adenylyl cyclase (sAC) ( IC₅₀ = 3-10 µM in vivo).

2350 | KH7 DataSheet

Alternate Name/Synonyms: 2-​(1H-​benzimidazol-​2-​ylthio)-​2-​[(5-​bromo-​2-​hydroxyphenyl)methylene]hydrazide,​ propanoic acid

Appearance: White solid

Formulation: N/A

CAS Number: 330676-02-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₅BrN₄O₂S

Molecular Weight: 419.3

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective inhibitor of soluble adenylyl cyclase (sAC)

MDL Number: MFCD01230899

PubChem CID: 6843191

SMILES: CC(C(=O)NNC=C1C=C(C=CC1=O)Br)SC2=NC3=CC=CC=C3N2

InChi: InChI=1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,19H,1H3,(H,20,21)(H,22,24)

InChi Key: GEHVZUUHMWNMAY-UHFFFAOYSA-N