Description
A selective inhibitor of soluble adenylyl cyclase (sAC) ( IC₅₀ = 3-10 µM in vivo). Displays little effect on transmembrane adenylyl cyclases. KH7 is not active against sAC in the presence of detergents. At concentrations above 50 µM, KH7 exhibits non-specific membrane disruption effects when used on cells.
KH7 is a selective inhibitor of soluble adenylyl cyclase (sAC) ( IC₅₀ = 3-10 µM in vivo).
Alternate Name/Synonyms: 2-(1H-benzimidazol-2-ylthio)-2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide, propanoic acid
Appearance: White solid
Formulation: N/A
CAS Number: 330676-02-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₅BrN₄O₂S
Molecular Weight: 419.3
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (~40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A selective inhibitor of soluble adenylyl cyclase (sAC)
MDL Number: MFCD01230899
PubChem CID: 6843191
SMILES: CC(C(=O)NNC=C1C=C(C=CC1=O)Br)SC2=NC3=CC=CC=C3N2
InChi: InChI=1S/C17H15BrN4O2S/c1-10(25-17-20-13-4-2-3-5-14(13)21-17)16(24)22-19-9-11-8-12(18)6-7-15(11)23/h2-10,19H,1H3,(H,20,21)(H,22,24)
InChi Key: GEHVZUUHMWNMAY-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |