KIAA0999 Antibody (C-term) [APR14349G]

KIAA0999 Antibody (C-term) [APR14349G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KIAA0999 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1233-1263 amino acids from the C-terminal region of human KIAA0999.

Cellular Localisation: Cytoplasm. Note=Locates to punctate structures within the cytoplasm on binding to YWHAZ.

Molecular Weight: 144851

Clone: Polyclonal

Gene Name: SIK3 (HGNC:29165)

Gene ID: 23387

Function: Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230) . Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable) . Prevents HDAC4 translocation to the nucleus (By similarity) .

Summary: Tissue Location: Expressed in chondrocytes.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Serine/threonine-protein kinase SIK3, Salt-inducible kinase 3, SIK-3, Serine/threonine-protein kinase QSK, SIK3, KIAA0999, QSK