Kininogen 1 polyclonal Antibody | BS90771

Kininogen 1 polyclonal Antibody | BS90771 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB IHC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200

Background: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action) ; (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Storage & Stability: Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Specificity: Kininogen 1 polyclonal Antibody detects endogenous levels of Kininogen 1 protein.

Molecular Weight: Predicted molecular weight: 48, 72 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: HMWK, KNG1, BDK, KNG, Alpha-2-thiol proteinase inhibitor, BDK, BK, Bradykinin, Bradykinin included, Fitzgerald factor, FLAUJEAC FACTOR, High molecular weight kininogen, HMWK, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, KNG, KNG1, KNG1, Low molecular weight growth-promoting factor, WILLIAMS FACTOR, Williams-Fitzgerald-Flaujeac factor Antibody

Immunogen: Recombinant protein within human Kininogen 1 aa 500-644.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A purified.

Pathway: