KIR2DS4 polyclonal Antibody | BS7683

KIR2DS4 polyclonal Antibody | BS7683 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IF

Application Range: WB 1:500 - 1:2000 IF 1:50 - 1:200

Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: KIR2DS4 polyclonal Antibody detects endogenous levels of KIR2DS4 protein.

Molecular Weight: ~ 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD158 antigen like family member I; CD158 antigen-like family member I; CD158i; CD158i antigen; CL 17; CL 39; CL17; CL39; KI2S4_HUMAN; Killer cell immunoglobulin like receptor two domains short cytoplasmic tail 4; Killer cell immunoglobulin-like receptor 2DS4; Killer inhibitory receptor 4 1 2; KIR antigen 2DS4; KIR1D; KIR2DS4; KIR412; KKA3; MGC120019; MGC125315; MGC125317; MHC class I NK cell receptor; Natural killer associated transcript 8; Natural killer cell inhibitory receptor; Natural killer-associated transcript 8; NKAT 8; NKAT-8; NKAT8; OTTHUMP00000199030; P58 natural killer cell receptor clone CL 39; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor; p58 NK receptor CL-39/CL-17;

Immunogen: Recombinant full length Human KIR2DS4.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: