KIRA6 | B2594

KIRA-6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC₅₀ = 0.6 µM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

KIRA-6 is an ATP-competitive IRE1α kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1α RNase kinase activity (IC₅₀ = 0.6 µM) and blocks oligomerization. It has been shown to inhibit IRE1α in vivo and to promote cell survival under ER stress.

B2594 | KIRA6 DataSheet

Alternate Name/Synonyms: KIRA 6, KIRA6, 1-(4-(8-Amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea, KIRA-6

Appearance: Crystalline solid

Formulation:

CAS Number: 1589527-65-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₂₅F₃N₆O

Molecular Weight: 518.54

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: ~20 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An ATP-competitive allosteric IRE1-α inhibitor

MDL Number:

PubChem CID: 73425700

SMILES: NC1=NC=CN2C1=C(C3=C(C=CC=C4)C4=C(NC(NC5=CC(C(F)(F)F)=CC=C5)=O)C=C3)N=C2C(C)(C)C

InChi: InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38)

InChi Key: NOHQEAFAESMMDX-UHFFFAOYSA-N