KLK3 (Kallikrein-3), human recombinant | 4727

Prostate-specific antigen, also known as Gamma-seminoprotein, Kallikrein-3, kallikrein-related peptidase 3, SemenoGelase, KLK3 and PSA, is a secreted protein which belongs to thepeptidase S1 family and Kallikrein subfamily. KLK3/Kallikrein 3 contains one peptidase S1 domain. KLK3/Kallikrein 3 is a glycoprotein produced almost exclusively by the prostate gland. KLK3/Kallikrein 3 is produced for the ejaculate where it liquifies the semen in the seminal coagulum and allows sperm to swim freely.It is also believed to be instrumental in dissolving the cervical mucous, allowing the entry of sperm. Human KLK3/Kallikrein 3 and human KLK2 are closely related products of the human kallikrein genes KLK3 and KLK2, respectively. Both KLK3/Kallikrein 3 and human kallikrein 2 are produced and secreted in the prostate and have important applications in the diagnosis of prostate cancer. Understanding the mechanism by which genetic variation in KLK3/Kallikrein 3 affects prostate cancer risk has important implications for study of the biological role of KLK3/Kallikrein 3 in prostate tumorigenesis.

4727 | KLK3 Kallikrein-3 human recombinant DataSheet

Biomolecule/Target: N/A

Synonyms: APS, KLK2A1, PSA, Hk3

Alternates names: Scatter Factor (SF), Hepatopoietin (HPTA), HGF, HGFB, F-TCF.

Taglines: A glycoprotein enzyme elevated in prostate cancer

NCBI Gene ID #: 3082

NCBI Gene Symbol: HGF

Gene Source: Human

Accession #: P14210

Recombinant: Yes

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g purified protein

Activity (Specifications/test method): N/A

Biological activity: ED is typically 10 to 50 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of the monkey epithelial cell line 4MBr-5.

Results: 10 to 50 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 70 kDa, single chain, glycosylated

Concentration: N/A

Appearance: Lyophilized protein

Physical form description: Lyophilized from sterile PBS, pH 7.4. (Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.)

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Amino acid sequence: N/A