KLK4 Antibody | 7445

KLK4 Antibody | 7445 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: KLK4 antibody was raised against a 15 amino acid peptide near the center of human KLK4.
The immunogen is located within amino acids 80 - 130 of KLK4 .

Research Area: Cancer, Cell Cycle

Tested Application: E, WB, IHC-P, IF

Application: KLK4 antibody can be used for detection of KLK4 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: KLK4 antibody is human specific. At least three isoforms of KLK4 are known to exist.

Positive Control 1: Cat. No. 1305 - Human Kidney Tissue Lysate

Positive Control 2: Cat. No. 10-401 - Human Kidney Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 28 kDa
Observed: 31kDa

Validation: N/A

Isoform: N/A

Purification: KLK4 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: KLK4 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: KLK4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: KLK4 Antibody : ARM1, EMSP, PSTS, AI2A1, EMSP1, KLK-L1, PRSS17, kallikrein, Kallikrein-4, Enamel matrix serine proteinase 1

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes having diverse physiological functions (1) . Kallikrein 4 (KLK4) , also known as prostase or EMSP1 (enamel matrix serine protease 1) , contains one peptidase S1 domain and the expression in prostate is regulated by hormone (1, 2) . Many kallikreins are implicated in carcinogenesis and have potential as novel cancer and other disease biomarkers (3) . KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) (4) .