KLRK1, human recombinant | 7356

KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

7356 | KLRK1 human recombinant DataSheet

Biomolecule/Target: KLRK1

Synonyms: NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D

Alternates names: NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D

Taglines: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules

NCBI Gene ID #: 20307

NCBI Gene Symbol: Ccl8

Gene Source: Human

Accession #: Q9Z121

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.

Concentration: 0.5 mg/ml

Appearance: Liquid

Physical form description: 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A