Description
KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
7356 | KLRK1 human recombinant DataSheet
Biomolecule/Target: KLRK1
Synonyms: NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D
Alternates names: NKG2-D type II integral membrane protein, CD314, D12S2489E, KLR, NKG2-D, NKG2D
Taglines: Plays a role as a receptor for the recognition of MHC class I HLA-E molecules
NCBI Gene ID #: 20307
NCBI Gene Symbol: Ccl8
Gene Source: Human
Accession #: Q9Z121
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 98%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100 ng/ml.
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 19.2 kDa (168 aa, 73-216 aa + His Tag), confirmed by MALDI-TOF.
Concentration: 0.5 mg/ml
Appearance: Liquid
Physical form description: 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A