Description
KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 (phosphodiesterase type 5) activity.
KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 (phosphodiesterase type 5) activity.
Alternate Name/Synonyms: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
Appearance: Off-white solid
Formulation: N/A
CAS Number: 774549-97-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₉H₁₇Cl₂N₃O₂S
Molecular Weight: 422.33
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A cystic fibrosis transmembrane conductance regulator (CFTR) corrector
MDL Number: N/A
PubChem CID: 1241327
SMILES: C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl
InChi: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |