KM-11060 | B1076

KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 (phosphodiesterase type 5) activity.

KM-11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It increases the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 (phosphodiesterase type 5) activity.

B1076 | KM-11060 DataSheet

Alternate Name/Synonyms: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

Appearance: Off-white solid

Formulation: N/A

CAS Number: 774549-97-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇Cl₂N₃O₂S

Molecular Weight: 422.33

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A cystic fibrosis transmembrane conductance regulator (CFTR) corrector

MDL Number: N/A

PubChem CID: 1241327

SMILES: C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl

InChi: InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2

InChi Key: GIEHIZKCIZLXLF-UHFFFAOYSA-N