KN-93 | 2524

Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.

KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5).

2524 | KN-93 DataSheet

Alternate Name/Synonyms: N-​[2-​[[[3-​(4-​chlorophenyl)-​2-​propen-​1-​yl]methylamino]methyl]phenyl]-​N-​(2-​hydroxyethyl)-​4-​methoxy-​benzenesulfonamide

Appearance: White solid

Formulation: N/A

CAS Number: 139298-40-1

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₉ClN₂O₄S

Molecular Weight: 501.04

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Ca²⁺/calmodulin-dependent kinase type II inhibitor

MDL Number: MFCD03788201

PubChem CID: 5312122

SMILES: CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC

InChi: InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

InChi Key: LLLQTDSSHZREGW-AATRIKPKSA-N