Description
Cell-permeable. KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5). More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes.
KN-93 is a potent inhibitor of Ca²⁺/calmodulin-dependent kinase type II (CaM kinase II) (IC₅₀ = 0.37 μM). It does not affect the activities of PKA, PKC, MLCK, or Ca2+-phosphodiesterase. Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC₅₀ = 307 nM for Kv1.5).
Alternate Name/Synonyms: N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-benzenesulfonamide
Appearance: White solid
Formulation: N/A
CAS Number: 139298-40-1
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₆H₂₉ClN₂O₄S
Molecular Weight: 501.04
Cell-Permeable?: Yes
Purity: ≥98%
Solubilities: DMSO (>40 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Ca²⁺/calmodulin-dependent kinase type II inhibitor
MDL Number: MFCD03788201
PubChem CID: 5312122
SMILES: CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
InChi: InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
InChi Key: LLLQTDSSHZREGW-AATRIKPKSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |