KPNA2 polyclonal Antibody | BS90777

KPNA2 polyclonal Antibody | BS90777 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB FC

Application Range: WB:1:500-1:2,000 FC:1:50-1:100

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: KPNA2 polyclonal Antibody detects endogenous levels of KPNA2 protein.

Molecular Weight: N/A

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: KPNA2, RCH1, SRP1, IMA1, Importin alpha 1, Importin alpha 2, Importin alpha 2 subunit, Importin alpha P1, Importin subunit alpha-1, IPO A1, IPOA 1, IPOA1, Karyopherin alpha 2, Karyopherin alpha 2 RAG cohort 1, Karyopherin alpha 2 subunit, Karyopherin subunit alpha-2, KPNA2, KPNA2 protein, Pendulin, QIP 2, QIP2, RAG cohort 1, RAG cohort protein 1, RCH 1, RCH1, SRP 1, SRP1 alpha, SRP1, SRP1-alpha, SRP1alpha,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: