KPTN Antibody (Center) [APR17047G]

KPTN Antibody (Center) [APR17047G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This KPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-273 amino acids from the Central region of human KPTN.

Cellular Localisation: Lysosome membrane. Cell projection, lamellipodium. Cell projection, stereocilium {ECO:0000250|UniProtKB:A0A1D5PJB7}. Note=Localization to lysosomes is amino acid-independent (PubMed:28199306) . Colocalizes with F-actin (PubMed:24239382) .

Molecular Weight: 48080

Clone: Polyclonal

Gene Name: KPTN (HGNC:6404)

Gene ID: 11133

Function: As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Kaptin, Actin-associated protein 2E4, KPTN