KRIBB11 | B1567

KRIBB11 is a Heat shock factor (HSF) inhibitor (IC₅₀ = 1.2 μM). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells.

KRIBB11 is a Heat shock factor (HSF) inhibitor (IC₅₀ = 1.2 μM). KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells.

B1567 | KRIBB11 DataSheet

Alternate Name/Synonyms: N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine

Appearance: Brown solid

Formulation: N/A

CAS Number: 342639-96-7

Structure Available?: N/A

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₃H₁₂N₆O₂

Molecular Weight: 284.28

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Heat shock factor (HSF) inhibitor

MDL Number: N/A

PubChem CID: 69894253

SMILES: CNC1=NC(=C(C=C1)[N+](=O)[O-])NC2=CC3=C(C=C2)NN=C3

InChi: InChI=1S/C13H12N6O2/c1-14-12-5-4-11(19(20)21)13(17-12)16-9-2-3-10-8(6-9)7-15-18-10/h2-7H,1H3,(H,15,18)(H2,14,16,17)

InChi Key: NDJJEQIMIJJCLL-UHFFFAOYSA-N