KT5720 | 2276

A derivative of the protein kinase inhibitor K252a (Cat. No. 2013). Acts as a potent, selective, ATP-competitive inhibitor of protein kinase A (PKA) (Ki = 60 nM). Has no effect on PKC, PKG and MLCK.

KT5720 acts as a potent, selective, ATP-competitive inhibitor of protein kinase A (PKA) (Ki = 60 nM).

2276 | KT5720 DataSheet

Alternate Name/Synonyms: (9R,10S,12S)-2,3,9,10,11,12-Hexahyd­ro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindol­o[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazoc­ine-10-carboxylic acid, hexyl ester

Appearance: Colorless solid

Formulation: N/A

CAS Number: 108068-98-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₁N₃O₅

Molecular Weight: 537.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~50 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and selective Protein kinase A (PKA) inhibitor

MDL Number: MFCD00132118

PubChem CID: 3844

SMILES: CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O

InChi: InChI=1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)

InChi Key: ZHEHVZXPFVXKEY-UHFFFAOYSA-N