KT5823 | 2164

Cell-permeable. KT5823 is a derivative of K-252a (Cat. No. 2013) that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234 µM). Inhibits other kinases at much higher concentrations (Ki’s for PKA = 4 μM and for MLCK=>10 μM).

KT5823 is a derivative of K-252a (Cat. No. 2013) that acts as a selective inhibitor of Protein kinase G (PKG) (Ki = 0.234 µM). Inhibits other kinases at much higher concentrations (Ki’s for PKA = 4 μM and for MLCK=>10 μM).

2164 | KT5823 DataSheet

Alternate Name/Synonyms: 2,​3,​9,​10,​11,​12-​hexahydro-​10R-​methoxy-​2,​9-​dimethyl-​1-​oxo-​ 9S,​12R-​epoxy-​1H-​diindolo[1,​2,​3-​fg:3’,​2’,​1’-​kl]pyrrolo[3,​4-​ i][1,​]benzodiazocine-​10-​carboxylic acid,​ methyl ester

Appearance: White solid

Formulation: N/A

CAS Number: 126643-37-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₂₅N₃O₅

Molecular Weight: 495.53

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A protein kinase G (PKG) inhibitor

MDL Number: MFCD09878278

PubChem CID: 3843

SMILES: CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC

InChi: InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3

InChi Key: QTYMDECKVKSGSM-UHFFFAOYSA-N