Ku-60019 | 9572

Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

9572 | Ku-60019 DataSheet

Alternate Name/Synonyms: (2R,​6S)​-2,​6-​dimethyl-​N-​[5-​[6-​(4-​morpholinyl)​-​4-​oxo-​4H-​pyran-​2-​yl]​-​9H-​thioxanthen-​2-​yl]​-​4-​morpholineacetamide

Appearance: Light yellow to yellow solid

Formulation: N/A

CAS Number: 925701-49-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₃N₃O₅S

Molecular Weight: 547.67

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and reversible ATM kinase inhibitor

MDL Number: N/A

PubChem CID: 15953870

SMILES: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6

InChi: InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+

InChi Key: SCELLOWTHJGVIC-BGYRXZFFSA-N