Description
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
Alternate Name/Synonyms: (2R,6S)-2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
Appearance: Light yellow to yellow solid
Formulation: N/A
CAS Number: 925701-49-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₃₀H₃₃N₃O₅S
Molecular Weight: 547.67
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and reversible ATM kinase inhibitor
MDL Number: N/A
PubChem CID: 15953870
SMILES: CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C=CC=C4C3)C5=CC(=O)C=C(O5)N6CCOCC6
InChi: InChI=1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChi Key: SCELLOWTHJGVIC-BGYRXZFFSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |