KX-392 dihydrochloride | B2189

KX-392 is a potent oral non-ATP competitive inhibitor of Src kinase and tubulin polymerization. KX2-391 shows steep dose-response curves against Huh7 (GI₅₀ = 9 nM), PLC/PRF/5 (GI₅₀ = 13 nM), Hep3B (GI₅₀ = 26 nM), and HepG2 (GI₅₀ = 60 nM), four hepatic cell cancer (HCC) cell lines.

KX-392 is a potent oral non-ATP competitive inhibitor of Src kinase and tubulin polymerization. KX2-391 shows steep dose-response curves against Huh7 (GI₅₀ = 9 nM), PLC/PRF/5 (GI₅₀ = 13 nM), Hep3B (GI₅₀ = 26 nM), and HepG2 (GI₅₀ = 60 nM), four hepatic cell cancer (HCC) cell lines.

B2189 | KX-392 dihydrochloride DataSheet

Alternate Name/Synonyms: 5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide hydrochloride; N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide dihydrochloride

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1038395-65-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₁Cl₂N₃O₃

Molecular Weight: 504.45

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Src kinase and tubulin polymerization

MDL Number: N/A

PubChem CID: 24989633

SMILES: C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4.Cl.Cl

InChi: InChI=1S/C26H29N3O3.2ClH/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29;;/h1-11,20H,12-19H2,(H,28,30);2*1H

InChi Key: CPTPOZGQCQXHJO-UHFFFAOYSA-N